Perforación timpánica y colesteatoma, una patología de niños y adultos / Tympanic perforation and cholesteatoma, a pathology of children and adults

INTRODUCCIÓN. La patología de oído es una enfermedad frecuente en nuestro medio, asociada a infecciones a repetición del oído, con la presencia de perforación timpánica y colesteatoma, que determinará la presencia de lesiones mucho más acentuadas en cuanto a la evolución auditiva o complicaciones locales o sistémicas. OBJETIVO. Determinar la asociación existente entre la presencia de colesteatoma y perforación timpánica en pacientes con otitis media crónica. MATERIALES Y MÉTODOS. Estudio epidemiológico analítico retrospectivo. Población de 4 733 y muestra de 75 pacientes para casos y 75 para controles basados en historias clínicas tomadas del sistema informático AS 400, que acudieron a la consulta externa de torrinolaringología del Hospital de Especialidades Carlos Andrade Marín en el periodo de enero de 2018 a diciembre de 2019; Criterios de inclusión para grupo de casos: Hombres y mujeres de 20 a 65 años de edad, diagnóstico de otitis media crónica, diagnóstico de colesteatoma ótico. Criterios de inclusión para grupo controles: Hombres y mujeres de 20 a 65 años de edad, no presentar diagnóstico de colesteatoma. RESULTADOS. Se observó una relación fuerte entre el poseer perforación timpánica y el desarrollo de colesteatoma con un valor de OR 33,14 con un IC al 95% de 31,94 ­ 34,34, con lo que se comprobó la hipótesis del estudio. Se determinó que la perforación timpánica es un factor de riesgo asociado con el desarrollo de colesteatoma en pacientes con otitis media crónica, la prevalencia de colesteatoma en relación a la edad estuvo en un 72% en pacientes de 41 a 65 años, con mayor predominancia en mujeres en un 57,3%. DISCUSIÓN. La presencia de perforación timpánica de acuerdo a lo observado es un factor de riesgo para el desarrollo de colesteatoma, ligado en su mayoría a cuadros de Otitis Media Crónica. CONCLUSIONES. Se confirmó que la perforación timpánica, es un factor de riesgo en el desarrollo del colesteatoma en los pacientes que tienen otitis media crónica, lo que demuestra la necesidad de manejo actualizado y continuo en pacientes con esta patología de oído. Se requieren estudios con muestras más amplias para determinar otros factores de riesgo como sexo, nivel de educación y edad que podrían influir en el desarrollo de colesteatoma.

INTRODUCTION. Ear pathology is a frequent disease in our environment, associated with repeated ear infections, with the presence of tympanic perforation and cholesteatoma, which will determine the presence of much more accentuated lesions in terms of auditory evolution or local or systemic complications. OBJECTIVE. To determine the association between the presence of cholesteatoma and tympanic perforation in patients with chronic otitis media. MATERIALS AND METHODS. Retrospective analytical epidemiological study. Population of 4 733 and sample of 75 patients for cases and 75 for controls based on clinical histories taken from the AS 400 computer system, who attended the Otorhinolaryngology outpatient clinic of the Carlos Andrade Marín Specialties Hospital in the period from January 2018 to December 2019; Inclusion criteria for case group: Men and women aged 20 to 65 years, diagnosis of chronic otitis media, diagnosis of otic cholesteatoma. Inclusion criteria for controls group: men and women aged 20 to 65 years, no diagnosis of cholesteatoma. RESULTS. A strong relationship was observed between having tympanic perforation and the development of cholesteatoma with an OR value of 33,14 with a 95% CI of 31,94 - 34,34, thus proving the study hypothesis. It was determined that tympanic perforation is a risk factor associated with the development of cholesteatoma in patients with chronic otitis media, the prevalence of cholesteatoma in relation to age was 72% in patients aged 41 to 65 years, with greater predominance in women in 57,3%. DISCUSSION. The presence of tympanic perforation according to what was observed is a risk factor for the development of cholesteatoma, mostly linked to Chronic Otitis Media. CONCLUSIONS. It was confirmed that tympanic perforation is a risk factor in the development of cholesteatoma in patients with chronic otitis media, which demonstrates the need for updated and continuous management in patients with this ear pathology. Studies with larger samples are required to determine other risk factors such as sex, education level and age that could influence the development of cholesteatoma.

Tacrolimus action pathways in an ointment base for hypertrophic scar prevention in a rabbit ear model

Abstract Background: Tacrolimus is used to prevent unaesthetic scars due to its action on fibroblast activity and collagen production modulation. Objectives: To evaluate the action pathways, from the histopathological point of view and in cytokine control, of tacrolimus ointment in the prevention of hypertrophic scars. Methods: Twenty-two rabbits were submitted to the excision of two 1-cm fragments in each ear, including the perichondrium. The right ear received 0.1% and 0.03% tacrolimus in ointment base twice a day in the upper wound and in the lower wound respectively. The left ear, used as the control, was treated with petrolatum. After 30 days, collagen fibers were evaluated using special staining, and immunohistochemistry analyses for smooth muscle actin, TGF-β and VEGF were performed. Results: The wounds treated with 0.1% tacrolimus showed weak labeling and a lower percentage of labeling for smooth muscle actin, a higher proportion of mucin absence, weak staining, fine and organized fibers for Gomori's Trichrome, strong staining and organized fibers for Verhoeff when compared to controls. The wounds treated with 0.03% tacrolimus showed weak labeling for smooth muscle actin, a higher proportion of mucin absence, strong staining for Verhoeff when compared to the controls. There was absence of TGF-β and low VEGF expression. Study limitations: The analysis was performed by a single pathologist. Second-harmonic imaging microscopy was performed in 2 sample areas of the scar. Conclusions: Both drug concentrations were effective in suppressing TGF-β and smooth muscle actin, reducing mucin, improving the quality of collagen fibers, and the density of elastic fibers, but only the higher concentration influenced elastic fiber organization.

Tratamento da orelha em abano, novas e simples táticas / A novel and simple technique for the treatment of protruding ears

Introdução: A orelha de abano é uma deformidade congênita frequente que pode gerar implicações psicológicas desde a infância. Várias táticas cirúrgicas são descritas para correção deste defeito, no entanto, intercorrências frequentemente observadas pela equipe eram a presença de relevos abruptos da cruz posterior da anti-hélice e as recidivas parciais do defeito. O objetivo deste trabalho é demonstrar uma tática cirúrgica que minimiza essas intercorrências. Métodos: Foram realizadas 65 otoplastias no Hospital Mater Dei, em Belo Horizonte, MG, no período entre 1995 e 2015. Utilizou-se um instrumento cirúrgico elaborado pela equipe de cirurgia plástica, semelhante a uma pinça hemostática de 16 cm. Todos os pacientes foram operados sob anestesia local e sedação assistida por anestesista em ambiente hospitalar. Resultados: A correção do defeito congênito foi alcançada em todos os casos com o uso de um método comum, mas que cursou com a proposição de táticas novas e simples visando facilitar o ato cirúrgico e adquirir os resultados que foram naturais e satisfatórios. Conclusão: As táticas propostas para a cirurgia de otoplastia em abano são simples, de fácil realização, agilizaram o tempo operatório e utilizaram materiais simples, de baixo custo e de fácil aquisição. Também foram alcançados resultados estéticos satisfatórios sem se observar os estigmas decorrentes da quebra da cartilagem auricular.

Introduction: Protruding ears represent a common congenital deformity that can generate psychological implications from childhood. Several surgical techniques have been described to correct this defect; however, clinicians frequently observe the intercurrence of abrupt relief of the posterior crus of the anti-helix and a partial relapse of the original defect. The objective of this study was to demonstrate a surgical technique that minimizes these complications. Methods: Sixty-five otoplasties were performed at Mater Dei Hospital, Belo Horizonte, MG, between 1995 and 2015. A surgical instrument similar to a 16-cm hemostatic forceps was developed by the plastic surgery team. All patients were operated under local anesthesia and sedation, under the supervision of an anesthesiologist in a hospital setting. Results: Correction of the congenital defect was achieved in all cases using a common method that was performed using a simple, novel technique that facilitates surgery and obtains natural and satisfactory results. Conclusion: The proposed techniques for otoplasty of protruding ears are simple, faster, and require easily obtainable and affordable materials. Satisfactory esthetic results were also achieved without observing the stigmas arising from atrial cartilage rupture.

Tratamento de deformidade auricular / Treatment of Auricular Deformity

Neste artigo, apresentamos um caso de uma deformidade auricular de difícil correção cirúrgica, envolvendo unidade escafo-helicoidal associada com a orelha proeminente em uma paciente de 25 anos de idade. Esta é uma malformação congênita incomum da orelha, o que resulta em uma borda helicoidal achatada, não curvilínea e dobrada sobre a escafa, comprometendo a aparência helicoidal. Foi proposto um tratamento cirúrgico com abordagem posterior e enxerto de cartilagem conchal à restauração do contorno borda helicoidal em um procedimento único. Esta nova abordagem proporciona um resultado agradável para o ouvido, principalmente por restaurar uma nova unidade escafo-helicoidal sem cicatriz na superfície orelha anterior e tratamento da orelha proeminente.

In this paper, we present a case of auricular deformity whose surgical correction is difficult, involving scapha-helical unit associated with prominent ear in a 25-year-old female patient. This is an uncommon congenital malformation of the ear, resulting in a flattened, straightened and folded helical rim over the scapha, compromising the helical appearance. The proposed surgical treatment involved posterior approach and conchal cartilage graft to the restoration of the helical rim contour in a single procedure. This new approach provides a fine result to the ear, particularly because it restores the scapha-helical unit with no scar on the surface of the anterior ear and also effectively treats the prominent ear.

Correção da hipertrofia do lóbulo auricular / Earlobe hypertrophy correction

Introdução: A orelha é uma estrutura da face que tem valor estético. As dimensões da orelha e aparência dos seus componentes anatômicos são modificados com a idade, doenças e práticas culturais que podem resultar em uma estética desagradável com o tempo. O lóbulo é um componente anatômico importante da orelha que é bastante influenciado esteticamente por estes fatores. Ele é composto por tecido adiposo e pele e pode sofrer mudanças na sua proporção e flacidez, as quais podem ser melhoradas, por meio procedimentos cirúrgicos, para ficarem esteticamente mais agradáveis, com o intuito de oferecer uma aparência mais proporcional ou jovem. Este trabalho descreve um caso de um paciente de 30 anos que considerou os lóbulos das suas orelhas desproporcionais ao resto da orelha e fez cirurgia para reduzi-los. Métodos: Foi realizado um procedimento cirúrgico simples, de recuperação rápida para reduzir o tamanho dos lóbulos do paciente por marcação e resseção de uma parte de cada lóbulo do paciente. Resultados: Os resultados se mostraram satisfatórios com lóbulos mais proporcionais ao resto das orelhas e melhora da estética do paciente. Conclusão: A técnica descrita neste trabalho para a redução de lóbulos auriculares hipertrofiados se mostrou eficaz.

Introduction: The ear is a structure of the face with important aesthetic value. The dimensions of the ear and the appearance of its anatomical components change with age, disease and cultural practices which can result in an aesthetically unpleasant form over time. The earlobe is an important anatomical part of the ear and is considerably influenced by the factors above. It is made of fatty tissue and skin and can undergo changes in its proportion and flaccidity, which may be improved by surgical procedures to make it more aesthetically pleasing, providing a more proportional or younger appearance. This article reports the case of a 30-yearold patient who considered his earlobes disproportionate in relation to the rest of his ears and underwent surgery to have them reduced. Methods: A simple and fast recovery surgical procedure was carried out delineating and resecting a part of each of the patient's earlobes. Results: The results proved to be satisfactory as the patient had more proportional earlobes in relation to the rest of his ears achieving aesthetic improvement. Conclusion: The technique described in this article to reduce hypertrophied earlobes proved to be efficient.

Post-aural nodular fasciitis

Nodular fasciitis is a rare benign lesion. Here we report a case of post-auricular nodular fasciitis, which was misdiagnosed by fine-needle aspiration cytology [FNAC] as pleomorphic adenoma. Physical examination of an 18-year-old male revealed a right post aural firm immobile mass. Radiology suggested the presence of a hypo-dense to iso-dense subcutaneous mass. The swelling was excised and sent for histopathological examination which suggested the diagnosis of nodular fasciitis. FNAC reported pleomorphic adenoma of unusual location should raise the suspicion of nodular fasciitis

possible protective role of aminoguanidine in gentamicin-induced ototoxicity in guinea pig: a histological and immunohistochemical study

Introduction: Gentamicin is an ototoxic drug affecting both auditory and vestibular cells. Reactive oxygen species might play important role in the molecular pathway of this ototoxicity. Aminoguanidine is one of the guanidine derivatives and is considered as an antioxidant therapy

Aim of the work: to investigate the possible protective effect of aminoguanidine on ototoxicity induced by gentamicin in guinea pig

Materials and methods: Twenty one adult male guinea pigs were used. They were divided into three groups, seven animals each. Group I: served as a control group. Group II: I.M. injection of gentamicin [80 mg/kg/day] was used for 14 days. Group III: animals received gentamicin in the same way as group II and then followed by aminoguanidine [100 mg/kg/ day] administration using a gastric tube for 14 days. At the end of experiment, the cochlea was excised and prepared for light [LM] and scanning electron microscope [SME] examination. Immunohistochemichal technique was done to detect iNOS. Morphometric and statistical studies were also done

Results: By LM and SME examination, the present study showed that aminoguanidine protected the structure of organ of Corti in the cochlea by decreasing the degeneration of hair cells and other supporting cells. It also showed a significant decrease in the iNOS immune-reactivity in organ of Corti, stria vascularis and bipolar cells in spiral ganglia compared to group II

Conclusion: Aminoguanidine is a promising and successful antioxidant therapy for ototoxicity

Desórdenes en el espectro de la neuropatía auditiva (DENA) / Auditory neuropathy spectrum disorder (ANSD)

Desórdenes en el espectro de la neuropatía auditiva (DENA) es el término más aceptado en la actualidad para definir la antes llamada neuropatía auditiva o desincronía auditiva. Su prevalencia es difícil de estimar debido a sus múltiples etiologías (hiperbilirrubinemia, enfermedades infecciosas, neuropatías sensoriomotoras, hereditarias y/o isquémico-hipóxicas). Clínicamente se manifiesta con alteraciones auditivas y comunicativas variables, desde una discapacidad leve o sin ella, hasta la sordera funcional profunda, que puede ser fluctuante o permanente. En los métodos diagnósticos no se evidencian los potenciales auditivos del tallo cerebral o se notan marcadamente anormales, y hay presencia de emisiones otoacústicas o de microfónicos cocleares. Para el tratamiento inicial de los desórdenes en el espectro de la neuropatía auditiva se sugiere hacer amplificación con audífonos en los casos leves, reservando el implante coclear para los estados más severos. El objetivo del artículo es hacer una revisión de la literatura acerca de los desórdenes en el espectro de la neuropatía auditiva.

Auditory Neuropathy Spectrum Disorders (ANSD) is the most currently accepted term to define the previously called auditory neuropathy or auditory dyssynchrony. Its prevalence is difficult to estimate due to multiple etiologies (hyperbilirubinemia, infectious diseases and sensory-motor, hereditary and/or ischemic-hypoxic neuropathies). Some individuals with AN have little or no communication difficulties while others are functionally deaf. Within the diagnostic criteria abnormal auditory nerve response in ABR are observed absent or markedly abnormal while otoacoustic emissions (OAEs) or the cochlear microphonic (CM) remain present and normal. Within the management of DENA is suggested that some children with ANSD appear to benefit from amplification and auditory based intervention while others require CI or other implants for the most severe cases. The objective of this article is to review the literature on disorders of the auditory neuropathy spectrum.

Associação entre Mycoplasma spp. e ácaros do conduto auditivo de bovinos / Mycoplasmas species associated with the ear mites in cattle

Esse estudo foi realizado com o objetivo de verificar a associação entre micoplasmas e ácaros (Raillietia auris e R. flechtmanni) no conduto auditivo de bovinos. Foram realizadas lavagens no conduto auditivo externo de 60 bovinos abatidos no Estado do Rio de Janeiro, Brasil. Para a lavagem dos condutos auditivos foi utilizada solução salina tamponada (PBS, pH 7.2) em seringas estéreis de 60mL. Para o isolamento de micoplasmas foram utilizados pools de ácaros por animal, lavados sucessivamente em 1mL de meio Hayflick modificado. Os lavados dos ácaros foram diluídos de 10-1 até 10-5 e repicados em meio Hayflick modificado, sólido e líquido e incubados a 37°C por 48-72 horas em microaerofilia. A identificação das espécies de micoplasmas foi realizada pelo teste da imunoperoxidase indireta (IPI). Verificou-se alta prevalência de ácaros do gênero Raillietia spp. 76,7% (46/60). O parasitismo por ácaros e micoplasmas foi verificado em 40 animais (74,1%), sendo esta associação significativa (p<0,001). Dos ácaros processados para isolamento de micoplasmas, 193 foram fêmeas e 25 machos. A frequência de Mycoplasma em Raillietia spp. foi de 81,2% (177/218) (p<0.001). Das fêmeas identificadas, 52,3% (101/193) foram R. auris e 47,7% (92/193) R. flechtmanni. A frequência de Mycoplasma nas fêmeas de R. auris foi de 75,2% (76/101) e na espécie R. flechtmanni foi de 88% (81/92) (P<0.05). As espécies de micoplasmas tipificadas pela IPI nos ácaros Raillietia auris foram: M. alkalescens 6,9%, M. arginini 3,4%, M. bovirhinis 9,2%, M. conjunctivae 18,4%, M. mycoides mycoides LC 8,0%, M. capricolum 5,7%. Em R. flechtmanni as espécies de micoplasmas identificadas foram: M. alkalescens 12,2%, M. arginini 1,0%, M. bovirhinis 18,9%, M. bovis 2,2%, M. conjunctivae 21,0%, M. mycoides mycoides LC 11,0% e M. capricolum 4,4%. As espécies de micoplasmas identificadas no conduto auditivo externo dos bovinos foram as mesmas presentes nos ácaros R. auris e R. flechtmanni. Os resultados confirmam que o conduto auditivo externo de bovinos é um habitat de Mycoplasma spp., incluindo espécies potencialmente patogênicas para os rebanhos, além dos ácaros R. auris e R. flechtmanni estarem associados com esses molicutes carreando-os em seu organismo.

This study was carried out to assess the association between of mycoplasmas species with ear mites Raillietia auris and R. flechtmanni in the external ear canal of 60 bovines at slaughter time from the State of Rio de Janeiro, Brazil. Steril syringes (60ml) loaded with buffer solution (PBS, pH 7.2) were used for the ear canal flushing. Were processed 218 mites for mycoplasma isolation. A pool of mites from each sampled bovine was washed five times sucessively in 1mL of liquid modified Hayflick´s medium. The washed mites obtained were diluted up to 10-1 at 10-5, inoculated in liquid and solid Hayflick´s media and incubated at 37ºC for 2-3 days, being the plates put into jar for the obtention of microaerofilia condition. The Typical colonies were typified by the indirect imunoperoxidase test (IPI) with paper discs satured with hyperimmune rabbit sera. In the studied bovine high prevalence was verified Raillietia spp. 76.7% (46/60). The parasitism by mycoplasmas and mites was verified in 40 animals (74.1%), this association was significant (p<0.001). Among the mites processed for isolation mycoplasmas 193 were female and 25 males. The frequency of Mycoplasma in Raillietia spp. was of 81.2% (177/218) (p<0.001). Of the females identified 52.3% (101/193) were R. auris and 47.7% (92/193) were R. flechtmanni. The frequency of Mycoplasma in the females of R. auris was of 75.2% (76/101) and 88% (81/92) in R. flechtmanni (P<0.05). The mycoplasmas species typified by IPI in the Raillietia auris mites were M. alkalescens 6.9%, M. arginini 3.4%, M. bovirhinis 9.2%, M. conjunctivae 18.4%, M. mycoides mycoides LC 8.0%, M. capricolum 5.7%. In the R. flechtmanni mites mycoplasmas species typified were M. alkalescens 12.2%, M. arginini 1.0%, M. bovirhinis 18.9%, M. bovis 2.2%, M. conjunctivae 21.0%, M. mycoides mycoides LC 11.0% e M. capricolum 4.4%. The species of identified mycoplasmas in the external ear canal bovine and mites were exactly the same. The results confirm that the external ear canal cattle's ear canal is also a mycoplasmas source, including potentially pathogenic species for cattle, and these mollicutes are closely related with mites Raillietia spp. that is carrier and this agent in your organism.

Corpo estranho em meato acústico externo: avaliação de 462 casos / Foreign-body in external auditory meatus: evaluation of 462 cases

Introdução: Desde 1950, foram realizados inúmeros estudos dos corpos estranhos em orelhas e vias aéreas superiores. São casos frequentes no pronto socorro e que, se não abordados adequadamente, podem acarretar várias complicações como trauma e perfuração de membrana timpânica, hemorragias de conduto, perda auditiva e otites. Objetivo: Determinar a idade, sexo, complicações e tipo de corpos estranhos em meato acústico externo de 462 pacientes atendidos em um hospital terciário. Método: Estudo retrospectivo dos casos de corpos estranhos de orelha removidos pelo serviço de Otorrinolaringologia de um hospital terciário no período de 1º de janeiro de 1999 a 31 de julho de 2006. Resultados: Os corpos estranhos mais encontrados foram os insetos. A maior incidência de corpo estranho em orelha foi encontrada na faixa etária acima dos 16 anos e no sexo masculino. As complicações ocorreram principalmente na faixa etária abaixo dos 6 anos. Conclusão: A prevalência de corpo estranho em orelha nos adultos é elevada. As complicações ocorrem principalmente na faixa etária de 0 a 6 anos. Em nosso serviço, os insetos são os mais frequentes e os responsáveis pela maior parte das complicações.

Introduction: Since 1950, a numberless of studies of the foreign-bodies in ears and upper airways were executed. They are usual cases in the emergency rooms and, if they are not rightly addressed, they can bring about several complications as trauma and tympanic membrane perforation, auditory meatus hemorrhagia, hearing loss and otitis. Objective: Establish the age, sex, complications and foreign-bodies' type in external auditory meatus of 462 patients attended in a tertiary hospital. Method: A retrospective study of the cases of ear' foreign-bodies removed by the otorhinolaryngology service of a tertiary hospital in the period of January 1, 1999 to July 31, 2006. Results: The insects were the foreign-bodies more found. The major incidence of foreign-body in an ear was found in the age group above 16 years old and, in the male sex. The complications occurred mostly in the age group below 6 years old. Conclusion: The foreign-body' prevalence in an ear of the adults is high. The complications occur mostly in 0 to 6 years old age group. In our service, the insects are the most frequents and the responsible for the major part of the complications.

[ case of hydroa vacciniforme with ear mutilation]

Hydroa vacciniforme is a rare acquired photodermatosis which usually presents in childhood. It is characterized by vesicle, crust and scar formation following exposure to sunlight. Vacciniform scars of face and dorsa of the hands are common features but oral ulcers and eye complications also occur rarely. Another rare manifestation of the disease is ear mutilation which is presented in this report

Anti-inflammatory activities of methanol extracts from various seaweed species.

Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml(-1) of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively IC50 values of U. pinnatifida were 10, 15, and 18 mg ml(-1) when inflammation symptoms of edema, erythema, and blood flow, respectively were measured. The IC50 of U. linza was 20, 26, and 31 mg ml(-1) when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence.

Treatment of ear lobe keloids by combined intralesional surgical excision followed by intralesional corticosteroid injection

Keloids are defined as dermal fibrotic lesions which are considered an aberration of wound healing process. Their etiology and pathogenesis are poorly understood. Different treatment modalities are described in literature and no one method has been found completely successful. In the present work we combined intralesional surgical excision followed by in-tralesional corticosteroid injections to improve the therapeutic outcomes. Thirty female patients with ear lobe keloids due to ear piercing, burn and trauma were included in this study. Keloids were excised intralesionaly followed by adjuvant intralesional injection of triamcinolone acetonide 3 weeks after excision. Injections were done once / week for 3 weeks, followed by another course of injections 6 weeks later. Cases were followed up every 2 months for one year: 2 cases [6.6%] had relapsed after 4 and 6 months post-operative respectively. Our results confirm the effectiveness of this technique in reducing the rate of recurrence of ear lobe keloids

Estudo das complicações na reconstrução de orelha / Complications of ear reconstruction surgery: a study

As particularidades da anatomia e a localização topográfica da orelha a tornam uma estrutura única no corpo humano, existindo diversas situações clínicas em que a sua reconstrução (total ou parcial) pode ser necessária. Devido à dificuldade técnica, as complicações pós-operatórias são frequentes...

The distinctive anatomic features and topography render the ear unique in the human body. Total or partial reconstruction of the ear may be required in many clinical conditions, but because technical difficulties are common, the rate of postoperative complications increases...

[Nodular colloid milium of the ears]

Colliod milium is a degenerative change, which is characterized clinically by development of multiple yellowish, translucent papules and nodules on the light exposed skin and histologically by the presence of colloid in the dermal papillae. This is a rare condition and has some variants. We report a case of colloid millium with nodular and plaque lesions on his ears. Our patient was a farmer with a history of more than 47 years chronic sun exposure and showed photoaging

Proposição de técnica para drenagem de otohematoma em cães / Planteamiento de técnica para drenaje de otohematoma en perros / Technical proposition for the drainage of aural hematoma in dogs

Cães que apresentam otohematoma, requerem uma intervenção clínica ou cirúrgica, que permita o restabelecimento da condição fisiológica e estética da orelha. No presente estudo são abordados os procedimentos utilizados na técnica para drenagem do otohematoma em 20 cães. Todos foram submetidos à drenagem e colocação de dreno, possibilitando o restabelecimento definitivo do pavilhão auricular, sem deformações por contração da pele, nos pontos de incisão cirúrgica

Dogs having aural hematoma need a quick clinical or surgical intervention which will allow the reestablishment of the physiological and esthetical condition of their ear. The present study approaches the procedures used in the draining technique of the aural hematoma in twenty dogs. All of those were submitted to the use of a drain, permitting the definitive reestablishment of the ear pinna without any deformations by contracting skin

Perros que presentan otohematoma requieren una intervención clínica o quirúrgica, que permita El reestablecimiento de la condición fisiológica y estética de la oreja. En el presente estudio son abordados los procedimientos utilizados en la técnica para drenaje de otohematoma en 20 perros. Todos fueron sometidos a drenaje y colocación de dreno, posibilitando el reestablecimiento definitivo del pabellón auricular, sin deformaciones por contracción de la piel

Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice

Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis. Delayed type hypersensitivity (DTH) is an immunologic response that has been frequently used as a correlate for protection against or sensitization to leishmania antigen. In BALB/c mice, L. tropica infection results in non-ulcerating disease, whereas L. major infection results in destructive lesions. In order to clarify the immunologic mechanisms of these 2 different outcomes, we compared the ability of these 2 leishmania species in induction of DTH response in this murine model. BALB/c mice were infected with L. major or L. tropica, and disease evolution and DTH responses were determined. The results show that the primary L. major infection can exacerbate the secondary L. major infection and is associated with DTH response. Higher doses of the primary L. major infection result in more disease exacerbation of the secondary L. major infection as well as higher DTH response. L. tropica infection induces lower DTH responses than L. major. We have previously reported that the primary L. tropica infection induces partial protection against the secondary L. major infection in BALB/c mice. Induction of lower DTH response by L. tropica suggests that the protection induced against L. major by prior L. tropica infection may be due to suppression of DTH response.